Key Publications

for complete publication list

Neuropeptide Research

Braga NE, Hoffmann W, Brierley SM, Muttenthaler M.

Trefoil factor family: unresolved questions and clinical perspectives. 

Trends in Biomedical Sciences, 2019 accepted (IF=15.7, Top 2% of Journal Category)

 

Muttenthaler M*, Asa A, Vetter I, Menon R, Busnelli M, Ragnarsoon L, Bergmary C, Arrowsmith S, Deuis, JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. 

Science Signaling, 2017; 10:508. Covered by major international news outlets  (IF=7.4, Top 10% of Category)

 

Di Giglio M, Muttenthaler M , Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood PF, Gloriam DE, Gruber CW.

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

Scientific Reports, 2017; 7:41002. (IF=5.2, Top 5% of Category)

 

Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B.

Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure.

Journal of Medicinal Chemistry, 2016; 1;59(15):7152-66. Chosen for ACS Editors' Choice  (IF=5.1, Top 5% of Category)

 

Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzmán F, Teixidó M, Giralt E.

Lipid bilayer crossing- the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier-shuttles.

Journal of the American Chemical Society, 2015; 114(11):5815-47. (IF=12.1, Top 5% of Category)

 

Dantas de Araujo, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King, GF, Brierley SM, Alewood PF.

Synthesis, structure and analgesic properties of selenoether oxytocin analogues in a mouse model of chronic abdominal pain.

Nature Communications, 2014; 5:3165. (IF=10.0, Top 5% of Category)

 

Gruber CW, Koehbach J, Muttenthaler M.

Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery.

Future Medicinal Chemistry, 2012; 4(14):1791-8. (IF=3.2, Top 25% of Category)

 

Gruber CW, Muttenthaler M.

Discovery of defense- and neuropeptides in social ants by genome-mining.

PloS One, 2012;7: e32559. (IF=4.2, Top 15% of Category)

 

Gruber CW, Muttenthaler M, Freissmuth M.

Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.

Current Pharmaceutical Design, 2010; 16: 3071-3088. (IF=3.7, Top 25% of Category)

Venom Drug Discovery

Jin AH*, Muttenthaler M*, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. 

Conotoxins: Chemistry and Biology. 

Chemical Reviews, 2019, ahead of print. *co-first author (IF=54.3, Top 1% of Category)

Herzig V, de Araujo A , Greenwood K, Chin Y, Windley M, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson G, Alewood PF, King G. Evaluation of chemical strategies for improving the stability and oral toxicity of insecticidal peptides. 

Biomedicines, 2018; 6(3) pii: E90 (IF=N/A, Top 20% of Category)

 

Akondi KB*, Muttenthaler M*, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF.

Discovery, synthesis and structure-activity relationships of conotoxins.

Chemical Reviews, 2014; 114:5815−5847. *co-first author (IF=45.8, Top 1% of Category)

 

Muttenthaler M, Dutertre S, Wingerd JS, Aini JW, Walton H, Alewood PF, Lewis RJ.

Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea.

Nautilus, 2012; 126-2: 47-56. (IF=0.4)

 

Muttenthaler M, Akondi Kalyana B, Alewood PF.

Structure-activity studies on alpha-conotoxins.

Current Pharmaceutical Design, 2011; 17: 4226-4241. (IF=3.7, Top 25% of Category)

 

Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu S-H, Armishaw CJ, C. I. A. Wang, R. J. Lewis, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF.

Solving the alpha-conotoxin folding problem – selenium-directed on-resin folding of potent and stable nicotinic acetylcholine receptor antagonists. 

Journal of the American Chemical Society, 2010; 132: 3514-3522. Featured in C&E News. (IF=10.2, Top 5% of Category)

 

Grishin AA, Muttenthaler M, Alewood PF, Adams DJ.

α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors.

Journal of Biological Chemistry, 2010; 285: 22254-22263. (IF=5.0, Top 25% of Category)

 

Dutertre S, Croker D, Daly NL, Andersson A, Muttenthaler M, Lumsden NG, Craik DJ, Alewood PF, Guillon G and Lewis RJ.

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.

Journal of Biological Chemistry, 2008; 283: 7100-7108. (IF=3.7, Top 25% of Category)

Peptide Chemistry

Muttenthaler M*, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood PF. 

On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. 

Australian Journal of Chemistry, 2019 ahead of print (IF=1.8)

Breger JC*, Muttenthaler M*, Delehanty JB, Thompson D, Oh E, Susumu K, Deschamps JR, Anderson GP, Field LD, Walper SA, Dawson PE, Medintz IL. 

Nanoparticle Cellular Uptake by Dendritic Wedge Peptides: Achieving Single Peptide Facilitated Delivery. 

Nanoscale, 2017; 9(29):10447. (IF=7.8, Top 5% of Journal Category)

 

Wan J, Mobli M, Brust A, Muttenthaler M, Andersson A, Ragnarsson L, Castro J, Vetter I, Huang JX, Nilsson M, Brierley SM, Cooper MA, Lewis RJ, Alewood PF.

Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses.

Australian Journal of Chemistry, 2016, 70(2): 162-171. (IF=1.5)

Muttenthaler M, Albericio F, Dawson PE.

Hydrogen fluoride cleavage for Boc solid phase peptide synthesis – methods, setup and safety.

Nature Protocols, 2015; 10(7):1067-83. (IF=9.7, Top 5% of Category)

 

Gemmill KB*, Muttenthaler M*, Delehanty JB, Stewart MH, Susumu K, Dawson PE, Medintz IL.

Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots.

Analytical and Bioanalytical Chemistry, 2013; 405(19): 6145-54. *co-first author (IF=3.8, Top 15% of Category)

Mobli M, Morgenstern D, King GF, Alewood PF, Muttenthaler M.

Site-specific pKa determination of selenocysteine residues in selenovasopressin by using 77Se NMR spectroscopy.          

Angewandte Chemie, International Edition, 2011; 50: 11952-11955. (IF=13.6, Top 5% of Category)

Muttenthaler M, Dantas de Araujo A, Andersson A, Dekan Z, Lewis RJ, Alewood PF.

Modulating oxytocin activity and plasma stability by disulfide bond engineering.

Journal of Medicinal Chemistry, 2010; 53: 8585-8596. (IF=5.4, Top 5% of Category)

Muttenthaler M, Ramos YG, Feytens D, Dantas de Araujo A, Alewood PF.

p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl group.        

Biopolymers 2010; 94: 423-432. (IF=2.7)

Muttenthaler M, Alewood PF.

Selenopeptide chemistry.

Journal of Peptide Science, 2008; 14: 1223-39. (IF=1.8)