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Key Publications

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(All our publications are open-access)

Perisic M, Woolcock K, Hering A, Mendel H, Muttenthaler M*.

Oxytocin and vasopressin signaling in health and disease.

Trends in Biochemical Sciences, 2024 (IF=14.3, Top 3% of Journal Category


Muttenthaler M*, King GF, Adams DJ, Alewood PF.

Trends in peptide drug discovery. 

Nature Reviews Drug Discovery, 2021; 20(4): 309-325. (IF=64.8, Top 1% of Journal Category)

Neuropeptide Research

Kalaba P, Sanchez de la Rosa C, Möller A, Alewood PF, Muttenthaler M*.

Targeting the oxytocin receptor for breast cancer management: A niche for peptide tracers.

Journal of Medicinal Chemistry, 2024, 67, 3, 1625–1640. (IF=8.0, Top 5% of Journal Category)

Wirth U, Raabe K, Kalaba P, Keimpema E, Muttenthaler M*, König B*. 

Photoswitchable probes of oxytocin and vasopressin. 

Journal of Medicinal Chemistry, 2023, 66(21):14853-14865. (IF=8.0, Top 5% of Journal Category)

Huiping L, Muttenthaler M*

High oxytocin receptor expression linked to increased cell migration and reduced survival in patients with triple-negative breast cancer. 

Biomedicines, 2022, 10(7):1595. (IF=6.1


Hering A, Jieu B, Jones A, Muttenthaler M* 

Approaches to improve the quantitation of oxytocin in human serum by mass spectrometry. 

Frontiers in Chemistry, 2022, 10:889154. (IF=6.6, Top 25% of Journal Category)


Che K, Muttenthaler M*, Kurzbach D.

Conformational selection of vasopressin upon V1a receptor binding. 

Computational and Structural Biotechnology Journal, 2021, 19:5826-5833. (IF=7.3, Top 5% of Journal Category)

Braga Emidio N, Meli R, Tran HNT, Baik H, Morisset-Lopez S, Elliott AG, Blaskovich MAT, Spiller S, Beck-Sickinger AG, Schroeder CI, Muttenthaler M*

Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. 

Journal of Medicinal Chemistry, 2021, 64(13): 9484-9495. (IF=7.4, Top 5% of Journal Category)

Dekan Z, Kremsmayr T, Keov P, Godin M, Teakle N, Dürrauer L, Xiang H, Gharib D, Bergmayr C, Hellinger R, Gay M, Vilaseca M, Kurzbach D, Albericio F, Alewood PF, Gruber CW, Muttenthaler M*.

Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin.  

Chemical Science, 2021. (IF=9.3, Top 5% of Journal Category)


Liu H, Gruber CW, Alewood PF, Möller A, Muttenthaler M*

The oxytocin receptor signalling system and breast cancer: a critical review. 

Oncogene, 2020, 39(37):5917-5932. (IF=8.0, Top 5% of Journal Category)

Braga Emidio N, Baik H, Lee D, Stürmer R, Heuer J, Elliott AG, Blaskovich MAT, Haupenthal K, Tegtmeyer N, Hoffmann W, Schroeder CI, Muttenthaler M

Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. 

Chemical Communications, 2020; 56(47):6420-6423. (IF=6.2, Top 10% of Journal Category)


Braga Emidio N, Hoffmann W, Brierley SM, Muttenthaler M.

Trefoil factor family: unresolved questions and clinical perspectives

Trends in Biomedical Sciences, 2019; 44(5), 387-390. (IF=15.7, Top 2% of Journal Category)


Muttenthaler M, Asa A, Vetter I, Menon R, Busnelli M, Ragnarsoon L, Bergmary C, Arrowsmith S, Deuis, JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, Gruber CW, Lewis RJ, Alewood PF.

Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. 

Science Signaling, 2017; 10:508. Covered by major international news outlets. (IF=7.4, Top 10% of Journal Category)


Di Giglio M, Muttenthaler M , Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood PF, Gloriam DE, Gruber CW.

Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

Scientific Reports, 2017; 7:41002. (IF=5.2, Top 5% of Journal Category)


Busnelli M, Kleinau G, Muttenthaler M, Stoev S, Manning M, Bibic L, Howell LA, McCormick PJ, Di Lascio S, Braida D, Sala M, Rovati GE, Bellini T, Chini B.

Design and characterization of superpotent bivalent ligands targeting oxytocin receptor dimers via a channel-like structure.

Journal of Medicinal Chemistry, 2016; 1;59(15):7152-66. Chosen for ACS Editors' Choice. (IF=5.1, Top 5% of Journal Category)


Arranz-Gibert P, Guixer B, Malakoutikhah M, Muttenthaler M, Guzmán F, Teixidó M, Giralt E.

Lipid bilayer crossing- the gate of symmetry. Water-soluble phenylproline-based blood-brain barrier-shuttles.

Journal of the American Chemical Society, 2015; 114(11):5815-47. (IF=12.1, Top 5% of Journal Category)


Dantas de Araujo, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King, GF, Brierley SM, Alewood PF.

Synthesis, structure and analgesic properties of selenoether oxytocin analogues in a mouse model of chronic abdominal pain.

Nature Communications, 2014; 5:3165. (IF=10.0, Top 5% of Journal Category)


Gruber CW, Koehbach J, Muttenthaler M.

Exploring bioactive peptides from natural sources for oxytocin and vasopressin drug discovery.

Future Medicinal Chemistry, 2012; 4(14):1791-8. (IF=3.2, Top 25% of Journal Category)


Gruber CW, Muttenthaler M.

Discovery of defense- and neuropeptides in social ants by genome-mining.

PloS One, 2012;7: e32559. (IF=4.2, Top 15% of Journal Category)


Gruber CW, Muttenthaler M, Freissmuth M.

Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors.

Current Pharmaceutical Design, 2010; 16: 3071-3088. (IF=3.7, Top 25% of Journal Category)

Venom Drug Discovery

Baumgartner M, Lang M, Holley H, Crepaz D, Hausmann B, Pjevac P, Moser D, Hof F, Beer A, Orgler E, Frick A, Khare V, Evstatiev R, Strohmaier S, Primas C, Dolak W, Köcher T, Kristaps K, Rath T, Neurath MF, Berry D, Makristathis A, Muttenthaler M*, Gasche C.

Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis. 

Gastroenterology, 2021, 161(4):1245-1256.e20. (IF=33.9, Top 2% of Journal Category).

Peschel A, Cardoso FC, Walker AA, Durek T, Stone MRL, Braga Emidio N, Dawson PE, Muttenthaler M*, King GF*.

Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances potency. 

Journal of Medicinal Chemistry, 2020, 63:12773-12785. (IF= 6.2, Top 5% of Journal Category)


Touchard A, Mendel HC, Boulogne I, Herzig V, Braga Emidio N, King GF, Triquigneaux M, Jaquillard M, Béroud R, De Waard M, Delalande O, Dejean A, Muttenthaler M*, Duplais C*.

Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venoms. 

ACS Pharmacology & Translational Science, 2020, 3:1211-1224 (new journal, IF prediction 5.0–7.5, Top 10–15% of Journal Category).

Mendel HC, Kaas Q, Muttenthaler M*

Neuropeptide signalling systems – an underexplored target for venom drug discovery. 

Biochemical Pharmacology, 2020, 114129. (IF=4.9, Top 15% of Journal Category)

Jin AH*, Muttenthaler M*, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. 

Conotoxins: Chemistry and Biology. 

Chemical Reviews, 2019, 119(21):11510-11549. *co-first author. (IF=54.3, Top 1% of Journal Category)

Herzig V, de Araujo A , Greenwood K, Chin Y, Windley M, Chong Y, Muttenthaler M, Mobli M, Audsley N, Nicholson G, Alewood PF, King G. Evaluation of chemical strategies for improving the stability and oral toxicity of insecticidal peptides. 

Biomedicines, 2018; 6(3) pii: E90 (IF=N/A, Top 20% of Journal Category)


Akondi KB*, Muttenthaler M*, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF.

Discovery, synthesis and structure-activity relationships of conotoxins.

Chemical Reviews, 2014; 114:5815−5847. *co-first author (IF=45.8, Top 1% of Journal Category)


Muttenthaler M, Dutertre S, Wingerd JS, Aini JW, Walton H, Alewood PF, Lewis RJ.

Abundance and diversity of Conus species (Gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea.

Nautilus, 2012; 126-2: 47-56. (IF=0.4)


Muttenthaler M, Akondi Kalyana B, Alewood PF.

Structure-activity studies on alpha-conotoxins.

Current Pharmaceutical Design, 2011; 17: 4226-4241. (IF=3.7, Top 25% of Journal Category)


Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu S-H, Armishaw CJ, C. I. A. Wang, R. J. Lewis, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF.

Solving the alpha-conotoxin folding problem – selenium-directed on-resin folding of potent and stable nicotinic acetylcholine receptor antagonists. 

Journal of the American Chemical Society, 2010; 132: 3514-3522. Featured in C&E News. (IF=10.2, Top 5% of Journal Category)


Grishin AA, Muttenthaler M, Alewood PF, Adams DJ.

α-Conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of α3β4 nicotinic acetylcholine receptors.

Journal of Biological Chemistry, 2010; 285: 22254-22263. (IF=5.0, Top 25% of Journal Category)


Dutertre S, Croker D, Daly NL, Andersson A, Muttenthaler M, Lumsden NG, Craik DJ, Alewood PF, Guillon G and Lewis RJ.

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides.

Journal of Biological Chemistry, 2008; 283: 7100-7108. (IF=3.7, Top 25% of Journal Category)

Peptide Chemistry

Hering A, Braga Emidio N, Muttenthaler M* 

Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides. 

Chemical Communications, 2022, 58(65), 9100-9103. (IF=6.2, Top 10% of Journal Category)

Kremsmayr T, Aljnabi A, Blanco-Canosa JB,Tran H, Braga Emidio N, Muttenthaler M.*

On the utility of chemical strategies to improve peptide gut stability.

Journal of Medicinal Chemistry, 2022, 65(8), 6191–6206. (IF=8.0, Top 5% of Journal Category) 

Braga Emidio N, Tran HNT, Andersson A, Dawson PE, Albericio F, Vetter I, Muttenthaler M*.

Improving the gastrointestinal stability of linaclotide.

Journal of Medicinal Chemistry, 2021, 64(12): 8384-8390. (IF=7.4, Top 5% of Journal Category)

Kremsmayr T, Muttenthaler M*.

Fmoc peptide synthesis of oxytocin-like peptides.

Book chapter in The Oxytocin System, in Methods in Molecular Biology, 2021, Springer Nature (eds. Kassiou M, Werry E, Reekie T). 

Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood PF. 

On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. 

Australian Journal of Chemistry, 2020, 73(4):327-333. (IF=1.8)

Breger JC*, Muttenthaler M*, Delehanty JB, Thompson D, Oh E, Susumu K, Deschamps JR, Anderson GP, Field LD, Walper SA, Dawson PE, Medintz IL. 

Nanoparticle Cellular Uptake by Dendritic Wedge Peptides: Achieving Single Peptide Facilitated Delivery. 

Nanoscale, 2017; 9(29):10447. (IF=7.8, Top 5% of Journal Category)


Wan J, Mobli M, Brust A, Muttenthaler M, Andersson A, Ragnarsson L, Castro J, Vetter I, Huang JX, Nilsson M, Brierley SM, Cooper MA, Lewis RJ, Alewood PF.

Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses.

Australian Journal of Chemistry, 2016, 70(2): 162-171. (IF=1.5)

Muttenthaler M, Albericio F, Dawson PE.

Hydrogen fluoride cleavage for Boc solid phase peptide synthesis – methods, setup and safety.

Nature Protocols, 2015; 10(7):1067-83. (IF=9.7, Top 5% of  Journal Category)


Gemmill KB*, Muttenthaler M*, Delehanty JB, Stewart MH, Susumu K, Dawson PE, Medintz IL.

Evaluation of diverse peptidyl motifs for cellular delivery of semiconductor quantum dots.

Analytical and Bioanalytical Chemistry, 2013; 405(19): 6145-54. *co-first author (IF=3.8, Top 15% of Journal Category)

Mobli M, Morgenstern D, King GF, Alewood PF, Muttenthaler M.

Site-specific pKa determination of selenocysteine residues in selenovasopressin by using 77Se NMR spectroscopy.          

Angewandte Chemie, International Edition, 2011; 50: 11952-11955. (IF=13.6, Top 5% of  Journal Category)

Muttenthaler M, Dantas de Araujo A, Andersson A, Dekan Z, Lewis RJ, Alewood PF.

Modulating oxytocin activity and plasma stability by disulfide bond engineering.

Journal of Medicinal Chemistry, 2010; 53: 8585-8596. (IF=5.4, Top 5% of Journal Category)

Muttenthaler M, Ramos YG, Feytens D, Dantas de Araujo A, Alewood PF.

p-Nitrobenzyl protection for cysteine and selenocysteine: A more stable alternative to the acetamidomethyl group.        

Biopolymers 2010; 94: 423-432. (IF=2.7)

Muttenthaler M, Alewood PF.

Selenopeptide chemistry.

Journal of Peptide Science, 2008; 14: 1223-39. (IF=1.8)

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